Importance of Malaria Vaccine. Challenges of Malaria Vaccine Essay

Importance of Malaria Vaccine. Challenges of Malaria Vaccine - Essay Example In essence, the female anopheles mosquito transmits the plasmodium parasite. According to Coleman and Tsongalis 2009, it leaves the parasite in the human blood in the process of feeding on the blood meal. However, â€Å"Anopheles gambiae, Anopheles arabiensis and Anopheles funestus†are the maintransmitters of malaria in human beings. All the malaria manifest through common symptoms like fever, although some patients progress to severe malaria that is often caused by the P. falciparum species. Essentially, it takes one to three days after infection for the infecting parasites to release the infection depending on their species. Additionally, merozoites are released through the lysis of infected erythrocytes with the inclusion of waste substances such as red membrane products, hemozoin pigments and glycosylphosphatidylinositol (GPI). The infectivity of red cells by the parasite of malaria like, P. falciparum brings about progressive together with mechanical alternation of the re d cells that can deteriorate over time into the life threatening complications of malaria Although, P.falciparum has devastatingly castigated as the major contribution to severe malaria all over the world. For instance, there have been severe infections and reports of death due to infections of P. vivax and P. knowlesi. Some pathophysilogical features like sponge biomass, reset and confiscation alter formality and restraint of parasitized erythrocyte. Endothelial activation, injury, dysfunction and altered thrombostasis have been found to entail the acquisition of severe malaria. This is common in cases of P. falciparum infection (Choffnes and Relman 2011). However, malaria’s chronicity is rare and if it happens it leads to induction of sterilizing immunity. Individuals who experience repeated exposures may be in dire need of re-exposure of the parasite if cured through drug treatment. Thus, there is a need into curbing the ease into which malaria parasite are capable of inva ding human hosts while at the same time minimizing the immune response arm (Coleman and Tsongalis 2009). Basically, two models of supporting the protection against the chances of infection of malaria through vaccination exist. The first type of vaccine entails immunization with irradiated sporozoites, which are meant to ensure maximum protection against possibility of malaria infection. The other type of vaccine entails the repeated exposure to malaria that induces immunity malaria infections and effective protection against any clinical manifestation of malaria. Importance of Malaria Vaccine Malaria has been rated among the fastest killer disease all over the world. Hence, much has to be done in order to curb the disease against causing deaths especially in infants, and the old people who have weak defence system toward diseases. In essence, malaria has not been controlled by the widespread deployment of existing control tools in most endemic areas. Moreover, there has been increas ed concern on the surfacing of insecticides and anti malarial drugs (Palmer and Reeder 2001). Vaccinations are been described as relative tools that are used to deliver and have played major roles toward the elimination of rinderpest, smallpox and other similar diseases. Never the less, the malaria vaccine is expected to provide direct individual protection against malaria infection and it clinical consequences. Additionally,, it is meant to decrease the rate of transmission of malaria infections better known as herd immunity. Immunization using Irradiated Sporozoites The possibility of giving safeguard against experimental sporozoite issues through the immunization by use of radiation attenuated sporozoites is evidenced in rodents, the natural rodents’